2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Melanocortin Receptor

Melanocortin Receptor

MC Receptor

Melanocortin Receptor

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The melanocortin (MC) receptors represent a subfamily of G-protein-coupled receptors (GPCRs) where the different subtypes are involved in a wide range of physiological functions such as pigmentation, steroid secretion, energy homeostasis, and food intake. The melanocortin receptor (MCR) family consists of five G-protein-coupled receptors (MC1R-MC5R). MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.

MCRs are activated by a variety of neuropeptides, termed melanocortins, that include the adrenocorticotropic hormone (ACTH) andα, β and γ-melanocyte-stimulating hormones (MSHs). Melanocortins derive from post-translational processing of the common polypeptide precursor pro-opiomelanocortin, expressed mainly in the hypothalamus and pituitary.

Melanocortin Receptor Isoform Specific Products:

Melanocortin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1208A
    PG-931 TFA
    		Agonist
    PG-931 TFA, an analog of SHU 9119 (HY-P0227), is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R(IC50=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo.
    PG-931 TFA
  • HY-P1213A
    JKC363 TFA
    		Antagonist
    JKC363 TFA, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC363 TFA blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect.
    JKC363 TFA
  • HY-P3924
    Agouti-Related Protein (54-82) (human)
    		Inhibitor
    Agouti-Related Protein (54-82) (human) (AGRP (54-82) (human)) is an amino-terminal 54-82 fragment of agouti-related protein (AGRP).
    Agouti-Related Protein (54-82) (human)
  • HY-RS08201
    Mc1r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc1r Mouse Pre-designed siRNA Set A
    Mc1r Mouse Pre-designed siRNA Set A
  • HY-RS08214
    Mc5r Rat Pre-designed siRNA Set A
    		Inhibitor

    Mc5r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc5r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc5r Rat Pre-designed siRNA Set A
    Mc5r Rat Pre-designed siRNA Set A
  • HY-RS08203
    MC2R Human Pre-designed siRNA Set A
    		Inhibitor

    MC2R Human Pre-designed siRNA Set A contains three designed siRNAs for MC2R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
    MC2R Human Pre-designed siRNA Set A
    MC2R Human Pre-designed siRNA Set A
  • HY-P3977
    ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)
    ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) is the 3-24 fragment of adrenocorticotropic hormone (ACTH). ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat) can be used for research of a variety of diseases, including cancer, immune diseases, cardiovascular disease.
    ACTH (3-24) (human, bovine, mouse, ovine, porcine, rabbit, rat)
  • HY-P1214A
    γ1-MSH TFA
    		Agonist
    γ1-MSH TFA is a melanocortin MC3 receptor agonist, with a Ki of 34 nM for the rat MC3 receptor. γ1-MSH TFA displays ~40-fold selectivity over MC4 (Ki=1318 nM).
    γ1-MSH TFA
  • HY-119808
    Terrein
    		Inhibitor
    Terrein is a melanogenesis inhibitor. Terrein induces apoptosis in breast cancer cell lines . Terrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa.
    Terrein
  • HY-RS08211
    Mc4r Rat Pre-designed siRNA Set A
    		Inhibitor

    Mc4r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mc4r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc4r Rat Pre-designed siRNA Set A
    Mc4r Rat Pre-designed siRNA Set A
  • HY-19648
    Ebiratide
    Ebiratide (HOE-427 free base) is an ACTH 4-9 derivative, which acts directly on the central nervous system and exhibits memory-enhancing efficacy. Ebiratide enhances acetycholine (ACh) metabolism in rat brain.
    Ebiratide
  • HY-P1726A
    MSG606 TFA
    		Antagonist
    MSG606 TFA is a potent human MC1 receptor antagonist (IC50=17 nM). MSG606 TFA also partial agonist at human MC3 and MC5 receptors (EC50 values are 59 and 1300 nM, respectively). MSG606 TFA exhibits binding affinity for A375 melanoma cells in vitro. MSG606 TFA reverses the induced hyperalgesia in female mice, with no effect in male mice.
    MSG606 TFA
  • HY-RS08207
    Mc3r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Mc3r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mc3r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Mc3r Mouse Pre-designed siRNA Set A
    Mc3r Mouse Pre-designed siRNA Set A
  • HY-18678
    Bremelanotide
    		99.69%
    Bremelanotide (PT-141) is an analogue of α-melanocyte-stimulating hormone (α-MSH). Bremelanotide activates the mPOA and other hypothalamic and limbic regions of the brain involved in sexual behavior. Bremelanotide can be used for researching hypoactive sexual desire disorders.
    Bremelanotide
  • HY-153660A
    Bivamelagon hydrochloride
    		Agonist
    Bivamelagon (MC-4R Agonist 2) hydrochloride is an orally active and BBB-penetrable MC4R agonist with EC50 values of 0.562 nM (Luci assay) and 36.5 nM (cAMP assay), and a Ki of 65 nM. Bivamelagon hydrochloride can be used for the research of diseases such as obesity and diabetes.
    Bivamelagon hydrochloride
  • HY-W267446
    6-Methoxy-4-methylcoumarin
    		Activator
    6-Methoxy-4-methylcoumarin is a 4-methylcoumarin derivative with an antitumor activity. 6-Methoxy-4-methylcoumarin activates melanin synthesis in B16F10 melanoma cells. 6-Methoxy-4-methylcoumarin is a pigmentation stimulator, and can be used for the study of skin conditions such as vitiligo.
    6-Methoxy-4-methylcoumarin
  • HY-N13879
    Amphistin
    		Inhibitor
    Amphistin is a melanogenesis inhibitor found in actinomycete. Amphistin inhibits the melanogenesis of B16 melanoma cells without affecting the growth of the cell.
    Amphistin
  • HY-B0288BR
    Fenoprofen Calcium hydrate (Standard)
    		Agonist
    Fenoprofen (LILLY-53858 (Standard)) (Standard) Calcium hydrate is the analytical standard of Fenoprofen Calcium hydrate (HY-B0288B). This product is intended for research and analytical applications. Fenoprofen is a nonsteroidal anti-inflammatory agent (NSAID) and inhibits cyclooxygenase (COX). Fenoprofen is a melanocortin receptors (MCRs) positive allosteric modulator (PAM). Fenoprofen also increases ERK1/2 activation in HEK293T cells. Fenoprofen has anti-arthritic activities and can be used for the study of rheumatoid arthritis and osteoarthritis.
    Fenoprofen Calcium hydrate (Standard)
  • HY-N13922
    Scytalol A
    		Inhibitor
    Scytalol A selectively inhibits biosynthesis of dihydroxynaphthalene melanin in Lachnellula sp. A32-89, but does not inhibit the growth of the strain.
    Scytalol A
  • HY-N14938
    Albocycline K3
    		Inhibitor
    Albocycline K3 is a melanogenesis inhibitor of microbial origin.
    Albocycline K3
Cat. No. Product Name / Synonyms Application Reactivity
Melanocortin Receptor Isoform Comparison

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